Team to expand frontiers of multicomponent reaction-based molecular synthesis

The experts create a main principle by which the polarity change of a reactive in a multicomponent process unchains domino reactions. Multicomponent reactions eased the developmenMulticomponent reactions eased the development of new molecules of pharmaceutical and biomedical interest. Recerca The synthesis of complex molecules such as drugs, requires a process that sometimes involves several phases that increase its cost and harden the access to the product. Now, a team of the UB has designed a new methodological approach that combines multicomponent reactions with domino type processes -continuous transformations on an only compoundto ease the synthesis of high structural complex molecules. The study, published in the journal Angewandte Chemie International Edition , is led by Professor Rodolfo Lavilla, from the Faculty of Pharmacy and Food Sciences and the Institute of Biomedicine (IBUB) of the University of Barcelona. The study, whose first signatories are researchers Ouldouz Ghasghaei and Marina Pedrola (UB-IBUB), counts on the participation of experts from Masaryk University (Czech Republic) and the Leibniz Research Institute for Environmental Medicine (Germany). Multicomponent reactions: more simplicity and efficiency Multicomponent reactions are protocols that ease the chemical synthesis of new high complexity and structural diversity compounds.