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The new experimental compound works through an epigenetic mechanism that acts not only on the symptoms of the disease, but directly on the molecular mechanisms that contribute to its progression. Health A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's disease.

A research team from the University of Valencia has analysed the scientific evidence available suggesting that cancer and cardiovascular disease are not independent conditions but share important metabolic and biological mechanisms.

People affected by human immunodeficiency virus (HIV), which causes AIDS, did not develop more severe forms of mpox - compared to HIV-negative people - during the multiregional outbreak of this disease that occurred in Spain in 2022.

Health The fear that cancer will progress or worsen is one of the most common concerns among people living with this disease. Identifying and measuring this concern is key to providing appropriate psychological care and improving patients' quality of life.

A study in mice provides new evidence on the mechanism of action of tirzepatide, a drug approved for treating obesity and type 2 diabetes. Health Tirzepatide is one of the drugs that has revolutionized the treatment of obesity and other conditions such as diabetes in recent years. Despite its clinical success, its precise molecular and cellular mechanisms are still not fully understood.

Research led by the University of Valencia has identified three key human strengths that determine psychological well-being: perspective, kindness and gratitude, integrated into a way of life aligned with values and virtues such as ethics, generosity and practical wisdom. The study, which employed a meta-analytic methodology, has been published in Clinical Psychology Review , one of the world-s leading journals in clinical psychology.

Research based on animal models demonstrates the protective effects of cognitive stimulation, identifies mechanisms for preserving brain function and reveals differences between sexes that point to the need to adapt therapeutic strategies with a gender perspective to address this neurodegenerative pathology.

New studies reveal that this hypersensitivity is a characteristic condition of the disease and is closely linked to symptom severity and brain responses in young people suffering from chronic pain. Health Children and adolescents affected by juvenile fibromyalgia show greater sensitivity to non-painful sensory stimuli, such as sounds and bright lights.

Researchers from Universidad Carlos III de Madrid (UC3M), the National Center for Cardiovascular Research (CNIC), and Yale University (USA) have published a comprehensive review article in the journal Cell that proposes a new framework for understanding neutrophils, the most abundant cells of the immune system.

A team from the Faculty of Medicine and Health Sciences and the Institute of Neurosciences at the University of Barcelona (UBneuro) has applied advanced artificial intelligence techniques to better understand why Huntington's disease can begin at very different ages in patients. This hereditary neurodegenerative condition, which causes motor, cognitive, and psychiatric impairments, is caused by a mutation in the HTT gene, which encodes the huntingtin protein.

Researchers at the Institute for Integrative Systems Biology (I2SysBio), a joint centre of the University of Valencia (UV) and the Spanish National Research Council (CSIC), have studied the effects o

Researchers identify the role of a key enzyme in rotavirus and norovirus infection, the leading causes of acute gastroenteritis A research team led by professor Jesús Rodríguez from the University of Valencia (Department of Microbiology) has identified the decisive role of fucosidases - enzymes present both in the human intestine and in the gut microbiota - in infection by rotavirus and norovirus.

When studying how fossil hominids moved, researchers usually analyse the morphology of bones - which is crucial for understanding the evolution of bipedalism - focusing mainly on muscle insertion sites. However, the potential information of studying other types of soft tissue, such as joint ligaments, is often overlooked.

Researchers uncover the role of the coronavirus "anchor": the least-known part of the Spike protein is key to infection A study by the University of Valencia (UV) and the Spanish National Research Council (CSIC) has revealed that a previously little-studied region of the SARS-CoV-2 coronavirus Spike protein is essential for the virus to enter human cells.

Researchers uncover the mechanisms of phage adaptation to eradicate clinically relevant bacteria A study led by Celia Ferriol-González and Pilar Domingo-Calap, researchers at the Institute for Integrative Systems Biology (a joint centre of the University of Valencia, UV, and the Spanish National Research Council, CSIC), reveals the evolutionary mechanism used by phages - viruses of therapeutic interest - to infect multidrug-resistant bacteria.

A new study describes a key molecular mechanism that explains how cells exchange information through extracellular vesicles (EVs), small particles with great therapeutic potential. The results, published in the Journal of Extracellular Vesicles , reveal that the Commander protein complex, previously known for its role in membrane recycling, also coordinates the entry and internal destination of vesicles within the cell.

Researchers discover that a porcine coronavirus uses an unexpected route to enter cells An international team led by the Institute for Integrative Systems Biology (I²SysBio) - a joint centre of the University of Valencia (UV) and the Spanish National Research Council (CSIC) - together with the Institut Pasteur in Paris, has identified, for the first time, a functional receptor for the porcine haemagglutinating encephalomyelitis virus, also known as porcine coronavirus PHEV.

An international study presents, for the first time, a complete system capable of controlling and releasing drugs within the body using magnetic microrobots. The system combines a clinical magnetic field, a precision catheter and biodegradable microcapsules that can be directed exactly to the specific point in the body where the drug needs to act.

Researchers reveal a new metabolic mechanism involved in resistance to lung cancer treatments A research team from the University of Valencia (UV) and the La Fe Health Research Institute (IIS La Fe) has identified a mechanism that explains why certain lung tumours with mutations in the EGFR gene stop responding to the most commonly used targeted therapies.

As the body ages, brown adipose tissue activity decreases, fewer calories are burned, and this can contribute to obesity and certain chronic cardiovascular diseases that worsen with age. A study led by the University of Barcelona has identified a key molecular mechanism in the loss of brown fat activity during ageing.