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The new experimental compound works through an epigenetic mechanism that acts not only on the symptoms of the disease, but directly on the molecular mechanisms that contribute to its progression. Health A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's disease.

A research team from the University of Valencia has analysed the scientific evidence available suggesting that cancer and cardiovascular disease are not independent conditions but share important metabolic and biological mechanisms.

Research based on animal models demonstrates the protective effects of cognitive stimulation, identifies mechanisms for preserving brain function and reveals differences between sexes that point to the need to adapt therapeutic strategies with a gender perspective to address this neurodegenerative pathology.

Warm spring temperatures are arriving earlier and earlier due to climate change, bringing forward the breeding season of a marine species that is crucial to the structure and biodiversity of coral reefs. Climate change is accelerating the arrival of warmer spring temperatures, and this phenomenon is affecting the conservation of many species.

Researchers from Universidad Carlos III de Madrid (UC3M), the National Center for Cardiovascular Research (CNIC), and Yale University (USA) have published a comprehensive review article in the journal Cell that proposes a new framework for understanding neutrophils, the most abundant cells of the immune system.

A team from the Faculty of Medicine and Health Sciences and the Institute of Neurosciences at the University of Barcelona (UBneuro) has applied advanced artificial intelligence techniques to better understand why Huntington's disease can begin at very different ages in patients. This hereditary neurodegenerative condition, which causes motor, cognitive, and psychiatric impairments, is caused by a mutation in the HTT gene, which encodes the huntingtin protein.

Researchers at the Institute for Integrative Systems Biology (I2SysBio), a joint centre of the University of Valencia (UV) and the Spanish National Research Council (CSIC), have studied the effects o

Researchers describe how tomato genes communicate to resist drought and improve fruit quality A study by the Institute of Integrative Systems Biology (I2SysBio), a joint centre of the University of Valencia and the Spanish National Research Council (CSIC), together with the Millennium Nucleus Phytolearning (Chile), has deciphered how tomato ( Solanum lycopersicum ) genes communicate with one another to coordinate essential processes such as fruit ripening and drought response.

The conservation of genome regulatory elements over long periods of evolution is not limited to vertebrates, as previously thought, but also in echinoderms (invertebrates). This is one of the most notable conclusions of a study published in the journal Nature Ecology & Evolution , which expands our knowledge of the mechanisms governing genomic regulation and biological evolution.

Researchers identify the role of a key enzyme in rotavirus and norovirus infection, the leading causes of acute gastroenteritis A research team led by professor Jesús Rodríguez from the University of Valencia (Department of Microbiology) has identified the decisive role of fucosidases - enzymes present both in the human intestine and in the gut microbiota - in infection by rotavirus and norovirus.

When studying how fossil hominids moved, researchers usually analyse the morphology of bones - which is crucial for understanding the evolution of bipedalism - focusing mainly on muscle insertion sites. However, the potential information of studying other types of soft tissue, such as joint ligaments, is often overlooked.

Researchers uncover the role of the coronavirus "anchor": the least-known part of the Spike protein is key to infection A study by the University of Valencia (UV) and the Spanish National Research Council (CSIC) has revealed that a previously little-studied region of the SARS-CoV-2 coronavirus Spike protein is essential for the virus to enter human cells.

Published in Nature, the atlas will be freely available to researchers around the world. An international team has published NeuMap, the first atlas to reveal the global architecture of neutrophils, showing how this "first line of defense" reorganizes to protect, remember, and heal. The study-led by scientists at the CNIC, Universidad Carlos III de Madrid, Yale University, and Westlake University-redefines our understanding of immunity.

Researchers uncover the mechanisms of phage adaptation to eradicate clinically relevant bacteria A study led by Celia Ferriol-González and Pilar Domingo-Calap, researchers at the Institute for Integrative Systems Biology (a joint centre of the University of Valencia, UV, and the Spanish National Research Council, CSIC), reveals the evolutionary mechanism used by phages - viruses of therapeutic interest - to infect multidrug-resistant bacteria.

A new study describes a key molecular mechanism that explains how cells exchange information through extracellular vesicles (EVs), small particles with great therapeutic potential. The results, published in the Journal of Extracellular Vesicles , reveal that the Commander protein complex, previously known for its role in membrane recycling, also coordinates the entry and internal destination of vesicles within the cell.

Researchers discover that a porcine coronavirus uses an unexpected route to enter cells An international team led by the Institute for Integrative Systems Biology (I²SysBio) - a joint centre of the University of Valencia (UV) and the Spanish National Research Council (CSIC) - together with the Institut Pasteur in Paris, has identified, for the first time, a functional receptor for the porcine haemagglutinating encephalomyelitis virus, also known as porcine coronavirus PHEV.

The transition from aquatic to terrestrial life has been one of the most significant evolutionary challenges. This decisive process in the evolution of life on Earth required a profound renewal of the genome. But what changes did genomes undergo to facilitate the transition to the terrestrial environment? Now, a study published in the journal Nature reconstructs the key genomic adaptations at different stages of the evolutionary transition to terrestrial ecosystems.

A research team from the INMA Project on childhood and environment - which includes the University of Valencia and the Fisabio Foundation of the Generalitat Valenciana among others - has analysed how pet ownership during the first years of life may be related to aspects of children's emotional and behavioural well-being.

The presence of reeds, an exotic and invasive plant capable of altering the ecological balance in the natural environment, could have positive effects on fish populations in rivers. This is according to a study published in the journal Science of The Total Environment and led by Professor Alberto Maceda, member of the Research Group FORESTREAM from the Faculty of Biology and the Biodiversity Research Institute (IRBio) at the University of Barcelona.

As the body ages, brown adipose tissue activity decreases, fewer calories are burned, and this can contribute to obesity and certain chronic cardiovascular diseases that worsen with age. A study led by the University of Barcelona has identified a key molecular mechanism in the loss of brown fat activity during ageing.