Postdoctoral Researcher in 3D Advanced Microsco
Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence--a seal that was awarded in 2011.
The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of life, while simultaneously promoting the training of outstanding researchers, technology transfer, and public communication of science. Its 27 laboratories and seven core facilities address basic questions in biology and are orientated to diseases such as cancer, metastasis, Alzheimer’s, diabetes, and rare conditions.
IRB Barcelona is an international centre that hosts 400 members and 30 nationalities. It is located in the Barcelona Science Park. IRB Barcelona forms part of the Barcelona Institute of Science and Technology (BIST) and the "Xarxa de Centres de Recerca de Catalunya" (CERCA).
IRB Barcelona is seeking a Postdoctoral Researcher to work at the Colorectal Cancer Laboratory directed by Dr. Eduard Batlle in a joint project with the Advanced Digital Microscopy Facility lead by Dr. Julien Colombelli, as part of the international consortium MACH3CANCER (mach3cancer.org). The project is funded by CRUK and AECC, (reference GEACC19006BAT from the Accelerator Awards of the ’Fundación de la Asociación Española contra el Cancer (FAECC)’).
The project aims to develop and apply high-throughput 3D live imaging technology that will contribute to the understanding of how cancer cells behave in complex 3D structures and will enable robust interrogation of responses to cancer therapy with single cell resolution. Screens will include longitudinal live cell imaging assays and use sophisticated phenotypic endpoints - with the potential to link to and inform subsequent single cell genomic and proteomic analysis. New, modular, open source, high content analysis (HCA) instrumentation and software tools are currently being developed to address the imaging challenges associated with 3D cell cultures and organoids. In particular, an Oblique Plane Microscope for live-cell High-Content Analysis (HCA-OPM) of patient-derived organoids, based on lightsheet illumination, is being implemented at IRB Barcelona by the inventors of OPM at Imperial College, based on their most recent prototype (see dOPM by Sparks et al: ?url=https%3A%2F%2Fdoi.org%2F10.1364%2FBOE.409781&module=jobs&id=802" target="_blank" rel="nofollow">https://doi.org/10.1364/BOE.409781 ), and will be a central resource to the project, in combination with other High-throughput screening resources (e.g. the LIPSI HTS confocal microscope recently installed at IRB Barcelona). Altogether, this will lead to enhanced understanding of the mechanisms of drug resistance and more effective high content screens for new therapies.
EXPERIENCE, KNOWLEDGE, SKILLS:
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HOW TO APPLY & SELECTION PROCESS:
Note: The strengths and weaknesses of the applications will be provided upon request.
’If you, as an applicant, have any suggestion or wish to make a complaint regarding the selection process, please contact us at the following email address: irbrecruitment.suggestionsirbbarcelona.org ’
IRB Barcelona - Institute for Research in Biomedicine
08028 BarcelonaDirections infoirbbarcelona.org +34 93 402 02 50
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In your application, please refer to myScience.es and reference JobID 802.
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