Laboratory Technician in Structural Biology (ref. LAB/21/11)

Closing Date
WorkplaceBarcelona, Spain

Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence--a seal that was awarded in 2011.

The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of life, while simultaneously promoting the training of outstanding researchers, technology transfer, and public communication of science. Its 27 laboratories and seven core facilities address basic questions in biology and are orientated to diseases such as cancer, metastasis, Alzheimer’s, diabetes, and rare conditions.

IRB Barcelona is an international centre that hosts 400 members and 30 nationalities. It is located in the Barcelona Science Park. IRB Barcelona forms part of the Barcelona Institute of Science and Technology (BIST) and the "Xarxa de Centres de Recerca de Catalunya" (CERCA).

IRB Barcelona seeks to recruit a structural biologist to join the Structural Characterization of Macromolecular Assemblies laboratory (Dr. Maria J. Macias, ICREA Professor).

The successful candidate will join our research team working in the project entitled Deciphering the interaction sites of Smad proteins with cofactors using high resolution structural biology, funded by the Spanish Ministry of Science and Innovation, the Spanish Research State Agency and the European regional development fund (ERDF) (ref: BFU2017-82675-P). The project requires the expression and purification of proteins and the determination of the transcription factors structures bound to targets, including other proteins and small molecule binders. Starting date 01-10-2021.


  • Expression and purification of proteins in mg scale and high purity
  • NMR and X-ray analysis of the data corresponding to the proteins and complexes


Must Have - Required: 

  • Experience: in Molecular and Structural biology (NMR/X-ray), Isothermal calorimetry and HTS assays. Software related to structural determination by NMR and X-ray 
  • Knowledge:  bachelor’s degree in Chemistry, Biochemistry, Pharmacy or similar
  • Skills: Good working knowledge of structural biology
  • Languages:  Fluency in English 


  • Knowledge: HTS assays for identification of small molecule binders
  • Skills: Experience with setting up HTS


  • Working conditions: Employed in compliance with Spanish legislation and regulations under a full-time contract. Employees receive the benefits of the Spanish Social Security system covering sickness, maternity/paternity leaves and injuries at work.
  • Estimated annual gross salary: Salary commensurate with experience and qualifications
  • International environment: Opportunity to join a prestigious, diverse and inclusive international research institution and to become a member of an established research group.
  • Benefits: Continuous training in a high-quality environment with unique professional career opportunities. 



  • Deadline for applications: 16/08/2021 (If no suitable candidate is found, the deadline will be extended) 
  • Number of positions available: 1
  • Selection process:
    • Pre-selection: Will be based on CV, motivation letter, experience, management of research and innovation. 
    • Interviews: Short-listed candidates will be interviewed.
    • Job offer: Will be sent to the successful candidate after the interview. 

Note: The strengths and weaknesses of the applications will be provided upon request.

If you, as an applicant, have any suggestion or wish to make a complaint regarding the selection process, please contact us at the following email address:  You will receive a response within a month.’


IRB Barcelona - Institute for Research in Biomedicine
08028 Barcelona Directions +34 93 402 02 50
In your application, please refer to and reference JobID 381.